Two different frameworks
Biology describes the pineal gland as an endocrine organ involved in melatonin signaling. Spiritual traditions use “third eye,” awakening and inner vision as symbolic or contemplative concepts.
Avoid the category error
A meditation experience can be meaningful without proving a physical change to pineal calcification. Established pineal physiology likewise does not validate every spiritual or supplement claim made in its name.
Practical takeaway
Approach meditation as a contemplative practice. Treat claims about curing disease, physically “opening” the gland or reversing calcification as separate claims requiring separate evidence.